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Re: Glutathione? Magnesium? » johnnyj

Posted by JLx on November 27, 2006, at 19:04:14

In reply to Exercise and Sex, posted by johnnyj on November 27, 2006, at 13:38:38

> I am off meds right now and have had this problem with working out since I had pneumonia 5 years ago. It seems to worsen my sleep. My mood rarely drops when I work out it just affects my sleep. It is quite profound too. I can have a good day and do a nice little workout (not too killer) and the next day I will feel terrible. I am still waking up early 4 or so and kind of sweating too.
>
> I wonder if seeing an endorcrinologist is a good idea? We all know the docs see our history or anixety and/or depression and say that is what is going on. But I thought working out is supposed to help this? It doesn't seem to matter when I work out either. I used to feel great working out and now it seems to worsen things. I do get really really tired after a short workout too. Since I have been off meds for a short time (last med about 3 weeks) maybe my body needs time to heal up first? It is so confusing and frustrating.
>
> Any ideas out there? Thanks
>
> johnnyj

I was just reading this recently about glutathione and exercise from this site: http://www.thorne.com/altmedrev/fulltext/glut.html

"Strenuous aerobic exercise can deplete antioxidants from the skeletal muscles, and sometimes also from the other organs. Exercise increases the body's oxidative burden by calling on the tissues to generate more energy. Making more ATP requires using more oxygen, and this in turn results in greater production of oxygen free radicals. Studies in humans and animals indicate GSH is depleted by exercise, and that for the habitual exerciser supplementation with GSH precursors may be a prudent policy.31

Some of the other exogenous factors known to deplete tissue GSH include: 1.) Dietary deficiency of methionine, an essential amino acid and GSH precursor. The liver uses 70 percent of the total dietary intake.4 2.) Ionizing radiation, whether as X-rays or ultraviolet from sunlight.32 3.) Tissue injury, as from burns,33 ischemia and reperfusion,34,37 surgery,35 septic shock,4,36 or trauma.37 4.) Iron overload, as in hemochromatosis and transfusional iron excess.25 Surgery can cause iron release from damaged tissue, and unbound iron catalyzes free radical generation via several putative mechanisms. 5.) Bacterial or viral infections, including HIV-1.3,4 6.) Alcohol intake is toxic through a number of differing pathways, some of which are free radical/oxidative in character.38"

Since this started after a bout with pneumonia which would be related to your immune system and glutathione, perhaps some glutathione boosting supplements and/or foods would help? Just guessing. I was reading up on glutathione and also copy/pasted these notes for myself:

"The health food industry promotes glutathione as a very efficient antioxidant to be used against a whole range of diseases. This runs counter to research, which suggests that glutathione is not orally bioactive. Nutritional supplement companies also offer N-acetylcysteine, which has been shown to increase glutathione in vivo.

Excess glutamate at synapses, which may be released in conditions such as traumatic brain injury, can prevent the uptake of cysteine, a necessary building block of glutathione. Without the protection from oxidative injury afforded by glutathione, cells may be damaged or killed.[3] http://en.wikipedia.org/wiki/Glutathione

According to this site which sells whey, http://www.1whey2health.com/food-sources-glutathione.htm to boost glutathione naturally: NAC, milk thistle, alpha lopoic acid, curcumin, selenium, undenatured whey protein isolate, balloon flower root, and foods such as asparagus, broccoli, avocado, spinach, raw eggs, (why RAW eggs?) garlic and fresh unprocessed meats.

Ray Sahelian http://www.raysahelian.com/glutathione.html says that cinnamon and cardomon boost glutathione and also, acetylcysteine, methyl donors, alpha lipoic acid, polyphenols such as Pycnogenol, and vitamin B12.

"The frequent use of acetaminophen (Tylenol) depletes glutathione peroxidase levels."

Exercise can also deplete magnesium, so you might try that too if you don't already take it. Perhaps a sedating type of magnesium, such as magnesium glycinate, would help you sleep. Some people need to take some calcium with their magnesium, some not.

JL


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URL: http://www.dr-bob.org/babble/alter/20061118/msgs/707999.html