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Re: what the heck is a partial agonist?

Posted by Elizabeth on January 20, 2000, at 9:19:12

In reply to Re: what the heck is a partial agonist?, posted by jd on January 19, 2000, at 23:26:20

My understanding is that a partial agonist is a drug that activates a receptor to less than the maximum extent. I don't know how to express this quantitatively, though. (Where's Adam when we need him! :-) I think that the partial agonists can behave as antagonists at high concentrations.

Buspar is a partial agonist at 5-HT1a receptors and, I believe, a full antagonist at D2 receptors.


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poster:Elizabeth thread:19073
URL: http://www.dr-bob.org/babble/20000112/msgs/19260.html