Posted by Ron Hill on April 4, 2003, at 17:37:07
In reply to Re: Larry Hoover Re: Ok- now who takes vitamins/ » McPac, posted by Larry Hoover on April 4, 2003, at 10:42:40
> The adenosine is recycled, freeing homocysteine. Here's where problems occur in depressives. Stress blocks the normal recycling of homocysteine to methionine. Homocysteine accumulates while SAMe is depleted. You could take SAMe, but that doesn't fix the homocysteine problem. In fact, it makes it worse.
Larry,
I hope we do not wear you out with our questions. Feel free to tell me to go away if it gets to be too much.
As I mentioned to you previously, about a year ago I had five months of good results using 200 mg/day of SAM-e to treat the atypical depressive phase of my BP II disorder. But then, rather suddenly, it started to make me VERY irritable (GRRRRRRRRRRRRRRRR!).
I took plenty of B-6, B-12 (sublingual, bioactive), and folate in an attempt to prevent the build up of homocysteine. As I understand it, when the body has proper levels of folic acid, vitamins B6 and B12, the enzymatic break-down of homocysteine occur either through remethylation, which converts it into methionine, or through transsulfuration, which turns it into glutathione.
> Stress blocks the normal recycling of homocysteine to methionine.
What stress related compound is the suspected culprit? Is it cortisol? In other words, does cortisol push the reaction equilibrium to the left?
Do you think that elevated levels of homocysteine could cause irritability?
Thanks Larry.
-- Ron
poster:Ron Hill
thread:215282
URL: http://www.dr-bob.org/babble/20030402/msgs/216278.html