Posted by chess on June 7, 2005, at 10:09:13
anyone know what this means ...
"plasma elimination half-life of quetiapine with the occupancy half-lives at dopamine D2 and serotonin 5-HT2 receptors. The ratio of D2 : 5-HT2 receptor occupancy was 1:2, which is similar to that seen with clozapine. The results showed that while the plasma half-life was 5.3 h, the D2-receptor occupancy declined more slowly (half-life, 6 - 6.4 h) and serotonin 5-HT2 occupancy fell even more slowly (half-life, 20 - 27 h)"
does that mean that a single dose of Seroquel antagonizes 5-HT2 receptors for up to 20-27 hours? and thus that Seroquel can be taken once-a-day for anxiety?
poster:chess
thread:509023
URL: http://www.dr-bob.org/babble/20050606/msgs/509023.html