Posted by Cairo on June 8, 2005, at 19:09:46
In reply to Re: Seroquel Pharmacology question » SLS, posted by chess on June 7, 2005, at 20:52:01
I once used low dose Risperdal to sucessfully combat a Fibromyalgia flare. The advice I received was to use it low dose, and don't take more than a couple of weeks. It was very effective at 0.125mg, but made symptoms worse at higher doses. If you down regulate the 5HT-2 receptors too much, do they become overly sensitive? Is that why the advice to use only a couple of weeks? I can't tolerate SSRIs at all, but was surprised that Risperdal worked that first time. A second trial some months later didn't seem to work on the flare. Why?
I'm very interested in this as we may be augmenting Zoloft with Seroquel for my daughter's social phobia. She has similar FMS-like symptoms and I want to understand the what and hows of using Seroquel as the pdoc doesn't even want to to use it and doesn't seem to know much about this type of use, but may give it a trial based on the recommendation of a doctor at UPa we saw.
What about dopamine receptors with Seroquel?
Cairo
>... SSRIs down-regulate 5HT-2 receptors after a month while seroquel directly antagonizes them on first use
>
poster:Cairo
thread:509023
URL: http://www.dr-bob.org/babble/20050606/msgs/509762.html