Posted by chess on June 7, 2005, at 15:26:47
In reply to Re: Seroquel Pharmacology question » ed_uk, posted by ed_uk on June 7, 2005, at 15:08:00
so seroquel's half-life is 6 hours, and it lifespan is 12 hours, but its effect (occupancy) on serotonin 5-HT2 receptors is 40-54 hours (half-life occupancy being 20 - 27 h)
so that means that seroquel's half-life of 6 hours doesn't mean that it only works for 6 hours, right?
is it that some seroquel molecules BIND to 5HT-2 recepetors for 40-54 hours (half-life occupancy being 20 - 27 h) while other seroquel molecules that don't bind and stay free in the bloodstream are metabolized out of the body by 12 hours?
or maybe that seroquel makes some kind of effect to 5HT-2 receptors that lasts longer than the drug itself lasts in the body (kind of how taking one aspirin in the morning keeps platelets from sticking to each other all day even though aspirin's half-life is only 4 hours)?
poster:chess
thread:509023
URL: http://www.dr-bob.org/babble/20050606/msgs/509170.html