Posted by linkadge on November 16, 2007, at 9:33:09
In reply to Re: bupropion compared to NRI's » linkadge, posted by Astounder on November 15, 2007, at 23:37:52
>Wellbutrin had immediately an effect at an acute >900 mg XL dosing, made me giddly and alert.
Geez, I hope you weren't just taking 900mg without working up to it. You could have seized.
>Weakly psychostimulant-like. Since I've read >there is tolerance to its DAergic effects
>(eventual DAT upregulation), I went for >desipramine instead.Thats a strange reason to choose a drug switch. I had read that DAT upregulation occured in the neucleus accumbens but not in other brain regions. Burpropion is also supposedly has higher affinity for NET in humans than DAT.
>I also don't like the idea of DAergic >metabolites floating around when I'm trying to >sleep.
So it gave you insomnia?
>Both of them cause plastic NET downregulation >after a few weeks, like all other NAergic >antidepessants. An effect that remains after >treatment ends
I'm confused by this statement. Are you suggesting that norepinephrine transport does not return to baseline uptake after NRI discontinuation? Or do you only mean shortly after?
Linkadge
poster:linkadge
thread:794699
URL: http://www.dr-bob.org/babble/20071115/msgs/795452.html