Posted by anonymoose on November 20, 2007, at 22:26:28
In reply to Re: bupropion compared to NRI's, posted by Astounder on November 16, 2007, at 10:43:22
Hi Astounder,
Thanks for your informative posts. Sorry to hijack this thread, but was wondering if I could ask a couple questions...
>Plus constant D2 receptor stimulation (not breaking while sleeping), is going to cause postsynaptic downregulation.
Would a dopamine agonist (e.g. Mirapex) also cause this postsynaptic downregulation? Also, you're referring to downregulation of DA transporter activity, right?
Which would cause more DAT downregulation, MAO-B inhibition (e.g. deprenyl) or D3 agonism (e.g. Mirapex)?
I think my dopamine system has been getting more and more screwed up over time (possible contributing factors: stress, chronic depression-induced stress, SSRIs, ritalin/adderall use). I've completely lost all sensitivity/response to caffeine, nicotine, alcohol, ritalin/adderall. Even orgasm no longer causes that rush of "pleasure chemicals" that you feel in your brain. Couple this with complete flattening of emotional response to formerly pleasureable stimuli (music, good conversation, art/beauty, etc.) and ever-worsening dysthymia/anhedonia/apathy... am I right in thinking this is a dopaminergic problem?
Thanks in advance. Any and all input is sincerely appreciated.
-John
poster:anonymoose
thread:794699
URL: http://www.dr-bob.org/babble/20071115/msgs/796254.html