Posted by hopefullynow on October 11, 2010, at 6:58:54
In reply to Re: Advice please re. clomipramine/anafranil, posted by kizzie2 on October 11, 2010, at 6:43:33
Hi there,
I'm sorry to hear that you're not stable at 50 mg/day.I think that clomipramine, as every AD, tends to lose its efectivness over time because it decreases noradrenergic and dopaminergic activity ( even that on paper its noradrenergic metabolite seems to be powerfull-it is not, comparing to serotonergic activity).That obsesivness/anxiety/agitation (which i know well)seems to be some form of akathisia, i dunno.All i know is that when i introduced an noradrenergic agent (nortryptiline/maprotiline/wellbutrin) my anxiety/agitation state disapeared.If i'd be in your place i'd try a tiny amount of nortryptiline...Good luck and keep us updated
Regards
> Hi
> Sadly things are still not stable for me.
> I am currently on 50mg a day.
> I have had a couple of periods of about 2 weeks where I have felt much better. But these dont last and then the depression/anxiety return badly.
>
> As I was very well on 25mg during 2008 and 2009 I am thinking of reducing slowly to 25mg to see if there is more consistency.
>
> For some reason I feel that at 50mg the anafranil INCREASES my obsessive anxiety. I know it is used as a treatment for OCD patients so this would seem to be impossible - but it really does seem to be the case with me.
>
> Because I have had such a difficult year I am having lots of thoughts that there is no way i can improve from this now. But I know i have to keep telling myself that there other possibilities.
>
> Thanks for reading.
>
> Kizzie x
poster:hopefullynow
thread:949082
URL: http://www.dr-bob.org/babble/20101009/msgs/965331.html