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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by krystee on March 28, 2006, at 15:48:57
Hearing all you guys talk about Nardil and Parnate is making me wanna try it. What is the starting dosage and therapeutic range of each? Will these drugs induce mania?
Posted by maxime on March 28, 2006, at 16:54:56
In reply to Nardil or Parnate, posted by krystee on March 28, 2006, at 15:48:57
> Hearing all you guys talk about Nardil and Parnate is making me wanna try it. What is the starting dosage and therapeutic range of each? Will these drugs induce mania?
Actually out of all the classes of anti-depressants, MAOIs are the least likely to cause mania.
Generally Nardil is prescribed if a person has a problem with social anxiety and depression. One side effect is weight gain.
Parnate is the more stimulating of the two and usually there is no weight gain.
Good luck getting a pdoc to prescribe one them to you!
Maxime
Posted by JaclinHyde on March 28, 2006, at 17:19:48
In reply to Re: Nardil or Parnate, posted by maxime on March 28, 2006, at 16:54:56
I have been on all 3 of the MAOI's for over 25 years and have found each of them a Godsend. The 3 drugs in this class (until Emsam which is coming out next month) are Nardil, Marplan & Parnate. I was on Marplan until it was realized that I was slightly bipolar which made Parnate the drug of choice but it is the least likely to cause mania and is safe for bipolars. It is very activating and causes weighloss on a whole whereas Nardil tends to cause weight gain and Marplan is somewhat weight neutral. But ymmv. Any more questions, fire away :-)
JH
Posted by krystee on March 28, 2006, at 18:19:34
In reply to Re: Nardil or Parnate, posted by JaclinHyde on March 28, 2006, at 17:19:48
Any more questions, fire away :-)
>
> JHActually several more questions...what is the usual starting dose for Parnate?
What is the actual therapeutic dose and how fast
do they titrate?What else do you take with your MAOIs?
Is alcohol forever forbidden with Parnate?
Posted by djmmm on March 28, 2006, at 19:50:39
In reply to Re: Nardil or Parnate » JaclinHyde, posted by krystee on March 28, 2006, at 18:19:34
> Any more questions, fire away :-)
> >
> > JH
>
> Actually several more questions...what is the usual starting dose for Parnate?
> What is the actual therapeutic dose and how fast
> do they titrate?
>
> What else do you take with your MAOIs?
>
> Is alcohol forever forbidden with Parnate?The typical starting dose for Parnate ranges between 10mg and 20mg taken once in the morning, then titrating to 30-40mg in 2 divided doses. The real therapeutic dose probably ranges from 40-80mg (divided in 2 doses), I Find 50-60mg works for me, although many take between 80-100mg.
I also take between .5mg and 1.5mg of Klonopin, a high potency, B-complex Vitamin, and a Multi amino acid supplement (GNC Pro Performance® 100% Whey Protein)
In MY experience, moderate amounts of any alcohol are fine.
Posted by Phillipa on March 28, 2006, at 22:32:45
In reply to Re: Nardil or Parnate, posted by djmmm on March 28, 2006, at 19:50:39
Maxie when do you start the parnate next week? Love Phillipa
Posted by TylerJ on March 29, 2006, at 10:08:21
In reply to Nardil or Parnate, posted by krystee on March 28, 2006, at 15:48:57
> Hearing all you guys talk about Nardil and Parnate is making me wanna try it. What is the starting dosage and therapeutic range of each? Will these drugs induce mania?
Both of these drugs are excellent choices. Neither causes mania. I also saw where you asked about alcohol. Some people drink a little while on MAOI's, but you have to be very careful...longer the age of the beer/wine, the higher the tyramine content and of course the danger. Some people swear bottled american beer is fine.
In making a choice between the two meds your diagnosis must definitely be a factor. Some people swear by Nardil (which can cause more weight gain) some swear by Parnate which is more activating but can cause some pretty nasty insomnia. No free lunches with psychiatric meds, as i am sure you already know. Talk to your doc see what he says. Oh yea, don't forget about Emsam...the "Patch". Good Luck!Tyler
Posted by Maxime on March 29, 2006, at 11:48:40
In reply to Re: Nardil or Parnate, posted by Phillipa on March 28, 2006, at 22:32:45
> Maxie when do you start the parnate next week? Love Phillipa
I should be able to start it next week sometime. The main provision is that I stop abusing ephedra. It's going to be hard. My eating disorder is raging right now and well ....
Maxime
Posted by JaclinHyde on March 29, 2006, at 12:50:34
In reply to Re: Nardil or Parnate » Phillipa, posted by Maxime on March 29, 2006, at 11:48:40
Be real careful Maxime. Even one slip up with ephedra while on Parnate can be your last. And why Parnate if you have an eating disorder? I have already dropped over 10lbs since starting it or is that what you are aiming for?
Love
JH
Posted by Maxime on March 29, 2006, at 19:14:12
In reply to Re: Nardil or Parnate, posted by JaclinHyde on March 29, 2006, at 12:50:34
> Be real careful Maxime. Even one slip up with ephedra while on Parnate can be your last. And why Parnate if you have an eating disorder? I have already dropped over 10lbs since starting it or is that what you are aiming for?
>
> Love
>
> JHHi, nope, I don't lose weight on Parnate. It's weight neutral for me. Of course if it helped me lose weight I would be really excited, but alas it does not. I know I have to be careful with the ephedra. I am already suffering bad side effect just with the ephedra alone. I have to stop taking it.
Maxime
Posted by Caedmon on March 30, 2006, at 0:08:00
In reply to Re: Nardil or Parnate, posted by Maxime on March 29, 2006, at 19:14:12
Based on my symptoms (anergia from atypical-type bipolar II depression, difficulty w/ cognition, Tx-resistant social phobia) and a desire to avoid weight gain and hypotension from Nardil. Although I think they are both good drugs, and if the Parnate doesn't work I may well try out Nardil.
I will start in about two weeks (have to d/c my current antidepressant)
Questions - which I have asked before, of many people, but I like to ask them again, since my health and safety could be on the line:
What can I take for nasal congestion? Is Vick's inhalers (l-methamphetamine) okay? Other OTC sprays? Or just saline spray? (Pseudoephedrine and phenylephrine are out of course. I'm just wondering about others.) What about a corticosteroid spray, e.g. fluticasone?
What about opioid analgesics? I have heard conflicting information on them. Demerol is horrible, but some people respond well to oxycodone or codeine? (Also a relevant question should I ever need a cough suppressant. Can't take dxm.)
- C
Posted by djmmm on March 30, 2006, at 5:32:43
In reply to Parnate for me, and questions, posted by Caedmon on March 30, 2006, at 0:08:00
> Based on my symptoms (anergia from atypical-type bipolar II depression, difficulty w/ cognition, Tx-resistant social phobia) and a desire to avoid weight gain and hypotension from Nardil. Although I think they are both good drugs, and if the Parnate doesn't work I may well try out Nardil.
>
> I will start in about two weeks (have to d/c my current antidepressant)
>
> Questions - which I have asked before, of many people, but I like to ask them again, since my health and safety could be on the line:
>
> What can I take for nasal congestion? Is Vick's inhalers (l-methamphetamine) okay? Other OTC sprays? Or just saline spray? (Pseudoephedrine and phenylephrine are out of course. I'm just wondering about others.) What about a corticosteroid spray, e.g. fluticasone?
>
> What about opioid analgesics? I have heard conflicting information on them. Demerol is horrible, but some people respond well to oxycodone or codeine? (Also a relevant question should I ever need a cough suppressant. Can't take dxm.)
>
> - CI've never had a probem with ANY over the counter or Rx nasal sprays (vicks, Oxymetazoline (Afrin), flonase, etc). I have used sudafed (in Allegra-D), and it made me very nervous/anxious, but my blood pressure was fine. I have even used my old Ventolin inhaler (for asthma)...still, no problems. I've taken hydrocodone, and oxycodone (for dental work)
In fact, I don't think I have had any significant blood pressure problems while on Parnate (or nardil)... I should stress that my experience with MAOIs is probably not the "norm". Everyone reacts differently.
I take Parnate 50-60mg and Klonopin .5 to 1.5mg
Posted by ed_uk on March 30, 2006, at 14:22:27
In reply to Parnate for me, and questions, posted by Caedmon on March 30, 2006, at 0:08:00
Hi :)
>Is Vick's inhalers (l-methamphetamine) okay?
I would not recommend taking the risk.
>Other OTC sprays?
Avoid decongestants.
>What about a corticosteroid spray, e.g. fluticasone?
Steroid sprays do not interact with MAOIs.
>What about opioid analgesics?
Do not take meperidine, propoxyphene or tramadol.
>Also a relevant question should I ever need a cough suppressant. Can't take DXM.
Cough supressants are rarely more effective than placebo. I would not recommend combining any cough supressants with MAOIs.
Kind regards
Ed
Posted by Caedmon on March 30, 2006, at 22:09:39
In reply to Re: Parnate for me, and questions » Caedmon, posted by ed_uk on March 30, 2006, at 14:22:27
This is the end of the thread.
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